Cardinals vs. Reds prediction: Why Cincinnati is favored to win Sunday's MLB matchup [5/24/2026]
Get St. Louis Cardinals vs Cincinnati Reds predictions for MLB Sunday.

MLB action continues on Sunday at 1:40 PM ET as the St. Louis Cardinals lock horns with the Cincinnati Reds at Great American Ball Park.
Brady Singer (2-4, 6.26 ERA) will start for the Reds, while the Cardinals have opted for Brycen Mautz (0-0, 0.00 ERA).
Based on the latest simulation results, Dimers' advanced MLB model gives the Reds a slight edge with a 53% win probability over the Cardinals.
This article offers an expanded analysis of Sunday's Cardinals vs. Reds matchup, including best bets and picks.
Cardinals vs. Reds prediction: Who will win and cover?
Our famous predictive model currently gives the Reds a 53% chance of beating the Cardinals.
According to our model, the Cardinals (+1.5) have a 63% chance of covering the run line, while the 10-run over/under has an equal 50-50 chance of hitting.
Cardinals vs. Reds odds [5/24/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Reds |
|---|---|---|
| Run Line | +1.5 (-196) | -1.5 (+162) |
| Moneyline | +105 | -120 |
| Total | o10 (-112) | u10 (-102) |
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Reds picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Reds -1.5 | +162 |
| Moneyline | Reds | -120 |
| Total | Under 10 | -102 |
According to our best MLB bets, the top play to make on this game is Under 10 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Reds game-day updates and essential details
Sunday's MLB matchup between the Reds and Cardinals at Great American Ball Park is scheduled to start at 1:40 PM ET.
- Who: St. Louis Cardinals vs. Cincinnati Reds
- Date: Sunday, May 24, 2026
- Time: 1:40 PM ET/10:40AM PT
- Venue: Great American Ball Park
Conclusion
We predict the Reds, with a 53% win probability, will likely beat the Cardinals in Sunday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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