Cubs vs. Brewers prediction: Why Milwaukee is favored to win Game 1 of NLDS [10/11/2025]

MLB action continues on Saturday at 8:08PM ET as the Chicago Cubs lock horns with the Milwaukee Brewers in Game 1 of the National League Division Series at American Family Field.

The Brewers will start Trevor Megill (0-0, 0.00 ERA in 2025 postseason), up against Drew Pomeranz (1-0, 0.00 ERA) for the Cubs.

Based on the latest simulations, Dimers' advanced MLB model projects the Brewers as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Cubs vs. Brewers predictions page.

Cubs vs. Brewers prediction: Who will win Game 1?

Using innovative machine learning and data, we have simulated the outcome of Saturday's MLB matchup between the Cubs and Brewers 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Brewers a 53% chance of defeating the Cubs.

According to our model, the Cubs (+1.5) have a 64% chance of covering the run line, while the over/under total of 7.5 runs has a 62% chance of going over.

Cubs vs. Brewers Game 1 odds [10/11/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Brewers
Run Line	+1.5 (-174)	-1.5 (+149)
Moneyline	+124	-135
Total	o7.5 (-105)	u7.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Brewers picks and best bets for Game 1

Our model's biggest edge in today's Cubs vs. Brewers matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Cubs vs. Brewers game-day updates and essential details

Saturday's MLB matchup between the Brewers and Cubs at American Family Field is scheduled to start at 8:08PM ET.

• Who: Chicago Cubs vs. Milwaukee Brewers
• Date: Saturday, October 11, 2025
• Time: 8:08PM ET/5:08PM PT
• Venue: American Family Field

Dimers' comprehensive preview of Saturday's Cubs vs. Brewers matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Brewers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Brewers, with a 53% win probability, will likely beat the Cubs on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Brewers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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