Anastasia Zakharova vs. Laura Siegemund prediction, odds, picks for US Open 2025

Anastasia Zakharova and Laura Siegemund will meet in the second round of the US Open 2025 on Thursday.

Based on updated simulation results, Dimers' advanced tennis model predicts Laura Siegemund as the most likely winner of the match.

For expanded analysis of Thursday's match, including best bets and picks, visit our interactive Zakharova vs. Siegemund predictions page.

Zakharova vs. Siegemund prediction: Who will win and advance to the Round of 32?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Thursday's Zakharova-Siegemund women's singles match 10,000 times as part of our tennis predictions coverage.

Our leading predictive model currently gives Siegemund a 61% chance of defeating Zakharova in the US Open 2025.

Additionally, Siegemund has a 58% chance of winning the first set, while the under 22.5 games has a 56% chance of hitting, according to our model.

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Anastasia Zakharova vs. Laura Siegemund odds

We have sourced the most up-to-date betting odds in America for this match, which are listed here:

Bet Type	Zakharova	Siegemund
Moneyline	+158	-189
First Set	+130	-164
Total Games	o22.5 (+100)	u22.5 (-135)

All odds are correct at the time of publication and are subject to change.

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Zakharova vs. Siegemund picks and best bets

Our model's strongest edge in today's Zakharova vs. Siegemund match is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best tennis picks and tennis best bets for every match throughout the year.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Zakharova vs. Siegemund updates and essential details

The US Open 2025 match between Anastasia Zakharova and Laura Siegemund is scheduled to commence on Thursday at 2:00PM ET.

• Who: Anastasia Zakharova vs. Laura Siegemund
• Date: Thursday, August 28, 2025
• Approx. Time: 2:00PM ET/11:00AM PT
• Tournament: US Open Women's Singles 2025
• Round: Second round

All dates and times mentioned in this article are United States Eastern Time unless otherwise noted.

Dimers.com's comprehensive preview of Thursday's Zakharova vs. Siegemund match includes our prediction, picks and the latest betting odds.

Before making any Anastasia Zakharova vs. Laura Siegemund picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

Key tennis betting guides and insights

• Learn how to bet on tennis and understand how tennis odds work
• Explore where sports odds come from and how they’re applied to tennis matches
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• Improve your chances with proven sports betting strategies that apply to tennis and more

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Conclusion

We predict Laura Siegemund, with a 61% win probability, will likely beat Anastasia Zakharova at the US Open 2025.

AI and automation have enhanced this article to quickly deliver accurate Zakharova vs. Siegemund insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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