Jun 26, 2026
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Read Article Diamondbacks vs. Cardinals prediction: St. Louis favored to win Wednesday's MLB matchup [6/24/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Arizona Diamondbacks vs St. Louis Cardinals predictions for MLB Wednesday.
The St. Louis Cardinals and Arizona dbacks will lock horns in MLB action at Busch Stadium on Wednesday, starting at 7:45 PM ET.
The Cardinals will have Matthew Liberatore (3-4, 5.23 ERA) as their starting pitcher, while the Diamondbacks have opted for Mitch Bratt (0-0, 0.00 ERA).
Based on the latest simulation results, Dimers' proven MLB model gives the Cardinals a slight edge with a 50.2% win probability over the Diamondbacks.
This article offers a closer look at Wednesday's Diamondbacks vs. Cardinals matchup, including best bets and picks.
Diamondbacks vs. Cardinals prediction: Who will win?
Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Diamondbacks and Cardinals, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Cardinals a 50.2% chance of defeating the Diamondbacks.
According to our model, the over/under total of nine runs has a 54.0% chance of going over,.
Diamondbacks vs. Cardinals odds [6/24/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Diamondbacks | Cardinals |
|---|---|---|
| Moneyline | -102 | -116 |
| Total | o9 (-110) | u9 (-103) |
All odds are correct at the time of publication and are subject to change.
Diamondbacks vs. Cardinals picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Moneyline | Diamondbacks | -102 |
| Total | Over 9 | -110 |
According to our best MLB bets, the top play to make on this game is Over 9 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Diamondbacks vs. Cardinals game-day updates and essential details
Wednesday's MLB action between the Cardinals and Diamondbacks at Busch Stadium is scheduled to start at 7:45 PM ET.
- Who: Arizona Diamondbacks vs. St. Louis Cardinals
- Date: Wednesday, June 24, 2026
- Time: 7:45 PM ET/4:45PM PT
- Venue: Busch Stadium
Conclusion
We predict the Cardinals, with a 50.2% win probability, will likely beat the Diamondbacks in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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