Cubs vs. Brewers prediction: Why Milwaukee is favored to win Friday's MLB matchup [6/26/2026]
Get Chicago Cubs vs Milwaukee Brewers predictions for MLB Friday.
The Milwaukee Brewers and Chicago Cubs will lock horns in MLB action at American Family Field on Friday, starting at 7:45 PM ET.
The Brewers will have Jacob Misiorowski (8-3, 1.45 ERA) as their starting pitcher, while the Cubs are going with Colin Rea (5-5, 4.99 ERA).
Based on updated simulations, Dimers' advanced MLB model predicts the Brewers as the most likely winner of the Cubs vs. Brewers game.
This article offers an expanded analysis of Friday's matchup, including best bets and picks.
Cubs vs. Brewers prediction: Who will win and cover?
Our independent predictive model currently gives the Brewers a 63.9% chance of defeating the Cubs.
According to our model, the Cubs (+1.5) have a 54.3% chance of covering the run line, while the over/under total of 7.5 runs has a 52.6% chance of going over,.
Cubs vs. Brewers odds [6/26/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Cubs | Brewers |
|---|---|---|
| Run Line | +1.5 (-104) | -1.5 (-115) |
| Moneyline | +215 | -250 |
| Total | o7.5 (+100) | u7.5 (-122) |
All odds are correct at the time of publication and are subject to change.
Cubs vs. Brewers picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cubs +1.5 | -104 |
| Moneyline | Cubs | +215 |
| Total | Over 7.5 | +100 |
According to our best MLB bets, the top play to make on this game is Cubs to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cubs vs. Brewers game-day updates and essential details
Friday's MLB matchup between the Brewers and Cubs at American Family Field is scheduled to commence at 7:45 PM ET.
- Who: Chicago Cubs vs. Milwaukee Brewers
- Date: Friday, June 26, 2026
- Time: 7:45 PM ET/4:45PM PT
- Venue: American Family Field
Conclusion
We predict the Brewers, with a 63.9% win probability, will likely beat the Cubs in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
