Reds vs. Pirates prediction: Why Pittsburgh is favored to win Friday's MLB matchup [6/26/2026]
Get Cincinnati Reds vs Pittsburgh Pirates predictions for MLB Friday.
The Pittsburgh Pirates and Cincinnati Reds will lock horns in MLB action at PNC Park on Friday, starting at 6:40 PM ET.
The Pirates will have Paul Skenes (6-7, 2.86 ERA) as their starting pitcher, while the Reds have opted for Andrew Abbott (5-4, 3.83 ERA).
Based on updated simulation results, Dimers' advanced MLB model projects the Pirates as the most likely winner of the Reds vs. Pirates game.
This article offers further insights into Friday's matchup, including best bets and picks.
Reds vs. Pirates prediction: Who will win and cover?
Our famous predictive model currently gives the Pirates a 63.2% chance of defeating the Reds.
According to our model, the Reds (+1.5) have a 53.9% chance of covering the run line, while the 7.5-run over/under has a 53.4% chance of going over,.
Reds vs. Pirates odds [6/26/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Reds | Pirates |
|---|---|---|
| Run Line | +1.5 (-125) | -1.5 (+108) |
| Moneyline | +176 | -200 |
| Total | o7.5 (-112) | u7.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Reds vs. Pirates picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Reds +1.5 | -125 |
| Moneyline | Reds | +176 |
| Total | Over 7.5 | -112 |
According to our MLB best bets, the top play to make on this game is Reds to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Reds vs. Pirates game-day updates and essential details
Friday's MLB game between the Pirates and Reds at PNC Park is scheduled to begin at 6:40 PM ET.
- Who: Cincinnati Reds vs. Pittsburgh Pirates
- Date: Friday, June 26, 2026
- Time: 6:40 PM ET/3:40PM PT
- Venue: PNC Park
Conclusion
We predict the Pirates, with a 63.2% win probability, will likely beat the Reds in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
