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Arizona State vs. Duke prediction: Duke favored to win in college football Week 19 [2025]
Get Arizona State vs Duke predictions for college football Wednesday.

Duke will take on Arizona State in Week 19 college football action at Sun Bowl on Wednesday, with kickoff at 2:00 PM ET.
Based on updated simulations, Dimers' advanced college football model predicts Duke as the most likely winner of the Arizona State vs. Duke game.
This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.
Arizona State vs. Duke prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the outcome of Arizona State vs. Duke 10,000 times as part of our college football predictions coverage.
Our famous predictive model gives Duke a 57% chance of defeating Arizona State. Our predicted final score has Duke winning 26-23.
According to our model, Arizona State (+4.5) has a 60% chance of covering the spread, while the 49.5-point over/under has an equal 50-50 chance of hitting.
Arizona State vs. Duke odds
We have sourced the best college football odds in America for this game, which are listed here:
| Bet Type | Arizona State | Duke |
|---|---|---|
| Spread | +4.5 (-110) | -4.5 (-110) |
| Moneyline | +160 | -180 |
| Total | o49.5 (-105) | u49.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Arizona State vs. Duke picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Arizona State +4.5 | -110 |
| Moneyline | Arizona State | +160 |
| Total | Over 49.5 | -105 |
According to our college football best bets, the top play to make on this game is Arizona State +4.5 at the spread.
Arizona State vs. Duke game-day updates and essential details
Wednesday's college football action between Duke and Arizona State at Sun Bowl is scheduled to begin at 2:00 PM ET.
- Who: Arizona State vs. Duke
- Date: Wednesday, December 31, 2025
- Time: 2:00 PM ET/11:00AM PT
- Venue: Sun Bowl
Conclusion
We predict Duke, with a 57% win probability, will likely beat Arizona State on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Arizona State vs. Duke insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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