Red Sox vs. Blue Jays prediction: Why Toronto is favored to win Thursday's MLB matchup [9/25/2025]

The Toronto Blue Jays and Boston redsox will meet in MLB action at Rogers Centre on Thursday, starting at 7:07PM ET.

Louis Varland (4-3, 3.10 ERA) will start on the mound for the Blue Jays, up against Brayan Bello (11-8, 3.34 ERA) for the Red Sox.

Based on the latest simulations, Dimers' proven MLB model predicts the Blue Jays as the most likely winner of today's game.

For expanded analysis of Thursday's matchup, including best bets and picks, visit our interactive Red Sox vs. Blue Jays predictions page.

Blue Jays vs. Red Sox prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Thursday's MLB matchup between the Red Sox and Blue Jays 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Blue Jays a 55% chance of beating the Red Sox.

According to our model, the Red Sox (+1.5) have a 63% chance of covering the run line, while the over/under total of 8 runs has a 60% chance of going over.

Red Sox vs. Blue Jays odds [9/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Red Sox	Blue Jays
Run Line	+1.5 (-181)	-1.5 (+155)
Moneyline	+118	-138
Total	o8 (-105)	u8 (-110)

All odds are correct at the time of publication and are subject to change.

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Red Sox vs. Blue Jays picks and best bets

Our model's biggest edge in today's Red Sox vs. Blue Jays matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Red Sox vs. Blue Jays game-day updates and essential details

Thursday's MLB game between the Blue Jays and Red Sox at Rogers Centre is scheduled to begin at 7:07PM ET.

• Who: Boston Red Sox vs. Toronto Blue Jays
• Date: Thursday, September 25, 2025
• Time: 7:07PM ET/4:07PM PT
• Venue: Rogers Centre

Dimers' full preview of Thursday's Red Sox vs. Blue Jays matchup includes our prediction, picks and the latest betting odds.

Before making any Red Sox vs. Blue Jays picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Blue Jays, with a 55% win probability, will likely beat the Red Sox on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Red Sox vs. Blue Jays insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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