Charleston Southern vs. Gardner-Webb prediction: Gardner-Webb favored to win in college football Week 6, 2025

Gardner-Webb will face Charleston Southern in Week 6 college football action at Ernest W. Spangler Stadium on Saturday, commencing at 1:30PM ET.

Based on the latest simulations, Dimers' proven college football model predicts the Gardner-Webb as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Charleston Southern vs. Gardner-Webb predictions page.

Charleston Southern vs. Gardner-Webb prediction: Who will win, cover the spread?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Charleston Southern vs. Gardner-Webb 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Gardner-Webb a 76% chance of beating Charleston Southern. Our predicted final score has Gardner-Webb winning 31-20.

According to our model, Charleston Southern (+12.5) has a 53% chance of covering the spread, while the 51.5-point over/under has a 53% chance of staying under.

Charleston Southern vs. Gardner-Webb odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Charleston Southern	Gardner-Webb
Spread	+12.5 (-105)	-12.5 (-113)
Moneyline	+370	-485
Total	o51.5 (-110)	u51.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Charleston Southern vs. Gardner-Webb picks and best bets

Our model's biggest edge in today's Charleston Southern vs. Gardner-Webb matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Charleston Southern vs. Gardner-Webb game-day updates and essential details

Saturday's college football action between Gardner-Webb and Charleston Southern at Ernest W. Spangler Stadium is scheduled to commence at 1:30PM ET.

• Who: Charleston Southern vs. Gardner-Webb
• Date: Saturday, October 4, 2025
• Time: 1:30PM ET/10:30AM PT
• Venue: Ernest W. Spangler Stadium

Dimers' in-depth preview of Saturday's Charleston Southern vs. Gardner-Webb matchup includes our prediction, picks and the latest betting odds.

Before making any Charleston Southern vs. Gardner-Webb picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Gardner-Webb, with a 76% win probability, will likely beat Charleston Southern on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Charleston Southern vs. Gardner-Webb insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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