Clemson vs. UNC prediction: Clemson favored to win in college football Week 6, 2025

Bill Belichick's North Carolina and Clemson will lock horns in Week 6 college football action at Kenan Stadium on Saturday, with kickoff at 12:00PM ET.

Based on updated simulation results, Dimers' advanced college football model projects the Clemson as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Clemson vs. UNC predictions page.

Clemson vs. UNC prediction: Who will win, cover the spread?

Using trusted machine learning and statistical analysis, we have simulated the result of Clemson vs. UNC 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Clemson an 86% chance of defeating North Carolina. Our predicted final score has Clemson winning 31-16.

According to our model, North Carolina (+21.5) has a 59% chance of covering the spread, while the 54.5-point over/under has a 58% chance of staying under.

Clemson vs. UNC odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Clemson	UNC
Spread	-21.5 (-118)	+21.5 (-112)
Moneyline	-700	+1060
Total	o54.5 (-114)	u54.5 (-114)

All odds are correct at the time of publication and are subject to change.

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Clemson vs. UNC picks and best bets

Our model's strongest edge in today's Clemson vs. UNC matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Clemson vs. UNC game-day updates and essential details

Saturday's college football matchup between UNC and Clemson at Kenan Stadium is scheduled to begin at 12:00PM ET.

• Who: Clemson vs. North Carolina
• Date: Saturday, October 4, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Kenan Stadium

Dimers' comprehensive preview of Saturday's Clemson vs. UNC matchup includes our prediction, picks and the latest betting odds.

Before making any Clemson vs. UNC picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Clemson, with an 86% win probability, will likely beat North Carolina on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Clemson vs. North Carolina insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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