College football picks today: Week 6 Saturday best bets include UC Davis vs. Cal Poly play [10/4/2025]

Today’s college football picks for October 4, 2025 are here, with Saturday’s college football best bets built on tens of thousands of data simulations analyzing the latest odds and matchups.

These college football best bets include matchups like UC Davis vs. Cal Poly and Duke vs. California, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge college football bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Saturday, October 4, 2025, including our complete set of picks and best bets for today and the week ahead.

List of college football picks tonight [10/4, updated 7:32PM ET]

After diving deep into the numbers and conducting thousands of simulations, our famous predictive analytics model has identified the best football bets for Saturday, October 4, 2025.

UC Davis vs. Cal Poly over 59.5 points (-110)

• Probability: 57.8%
• Edge: 5.4%
• Matchup: UC Davis vs. Cal Poly (8:00PM ET, Saturday)

Our model has pinpointed a high-probability college football betting opportunity tonight, which comes in the UC Davis vs. Cal Poly matchup. We recommend an over/under bet on over 59.5 points at -110 odds, with our analysis showing a 57.8% chance of hitting and a compelling edge of 5.4%.

California +2.5 (+100)

• Probability: 52.1%
• Edge: 2.1%
• Matchup: Duke vs. California (10:30PM ET, Saturday)

Our model has found another strong college football bet for Saturday's sports action, this time in the matchup between Duke and California. We suggest placing a spread wager on California +2.5 at +100 odds, with a 52.1% probability delivering a 2.1% edge.

Cal Poly ML (+260)

• Probability: 28.5%
• Edge: 2.7%
• Matchup: UC Davis vs. Cal Poly (8:00PM ET, Saturday)

Our model has found another strong college football bet for tonight's college football action, this time in the UC Davis vs. Cal Poly game. We recommend a bet on Cal Poly ML at +260 odds. Our projections shows a 28.5% probability and 2.7% edge for this wager.

NCAAF best bets: Saturday, 10/4/2025

As of 7:32PM ET, here are our top three college football bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
UC Davis vs. Cal Poly	Over 59.5 Points	-110 @ FanDuel	57.8%	5.4%
Duke vs. California	California +2.5	+100 @ FanDuel	52.1%	2.1%
UC Davis vs. Cal Poly	Cal Poly ML	+260 @ BetMGM	28.5%	2.7%

Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to four NCAAF picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for October 4, 2025.

List of upcoming college football games to bet on now

• Tulsa vs. Memphis (8:00PM ET, Saturday)
• UC Davis vs. Cal Poly (8:00PM ET, Saturday)
• Montana vs. Idaho State (8:00PM ET, Saturday)
• Nevada vs. Fresno State (10:30PM ET, Saturday)
• Duke vs. California (10:30PM ET, Saturday)

Bet365 bonus code "DIMERS" — perfect for college football Saturday betting

To make the most of Saturday's college football best bets, including the UC Davis vs. Cal Poly matchup, check out the new Bet365 bonus code "DIMERS" that unlocks $200 in bonus bets from a $5 bet – win or lose. Don't miss out!

More about college football

The bets on this page form part of our college football player props and college football best bets series.

For more NCAAF betting content, we have college football betting news and the latest National Championship odds and predictions.

Conclusion

Our college football best bets are locked and loaded for October 4, 2025, featuring plays such as over 59.5 points in the UC Davis vs. Cal Poly matchup and California +2.5. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college football insights quickly, with human oversight ensuring high editorial quality. Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

Note: Clicking links to our sportsbook partners may earn us a referral fee. Learn about how we review products and services.