Colorado vs. TCU prediction: Why TCU is favored to win in college football Week 6, 2025

TCU will take on Colorado in Week 6 college football action at Amon G. Carter Stadium on Saturday, starting at 7:30PM ET.

Based on updated simulations, Dimers' advanced college football model predicts the TCU as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Colorado vs. TCU predictions page.

Colorado vs. TCU prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the outcome of Colorado vs. TCU 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives TCU a 76% chance of defeating Colorado. Our predicted final score has TCU winning 33-22.

According to our model, Colorado (+13.5) has a 53% chance of covering the spread, while the over/under total of 57.5 points has a 52% chance of going over.

Colorado vs. TCU odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Colorado	TCU
Spread	+13.5 (-105)	-13.5 (-110)
Moneyline	+420	-500
Total	o57.5 (-102)	u57.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Colorado vs. TCU picks and best bets

Our model's strongest edge in today's Colorado vs. TCU matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Colorado vs. TCU game-day updates and essential details

Saturday's college football matchup between TCU and Colorado at Amon G. Carter Stadium is scheduled to commence at 7:30PM ET.

• Who: Colorado vs. TCU
• Date: Saturday, October 4, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Amon G. Carter Stadium

Dimers' in-depth preview of Saturday's Colorado vs. TCU matchup includes our prediction, picks and the latest betting odds.

Before making any Colorado vs. TCU picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Sports betting deal available for NCAAF Saturday

To make the most of Saturday's big day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that grants you $200 in bonus bets from a $5 bet — win or lose.

Plus, find out all the details on the BetMGM x Dimers Pro offer which provides a great option for those looking to expand their sports betting horizons. Don't miss out!

Conclusion

We predict TCU, with a 76% win probability, will likely beat Colorado on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Colorado vs. TCU insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Keep up with the latest college football news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the latest projections for the national title game and major conferences.