Daniil Medvedev vs. Flavio Cobolli prediction, odds, picks for ATP Madrid Open 2026

Daniil Medvedev will square off with Flavio Cobolli in the round of 16 at the ATP Madrid event on Tuesday.

Based on updated simulation results, Dimers' proven tennis model projects Daniil Medvedev as the most likely winner of the Medvedev vs. Cobolli match.

This article offers a closer look at Tuesday's match, including best bets and picks.

Medvedev vs. Cobolli prediction: Who will win and advance to the quarterfinals?

Using powerful machine learning and data, we have simulated the outcome of Tuesday's Medvedev-Cobolli men's singles match, forming part of our tennis predictions coverage.

Our independent predictive model gives Medvedev a 53% chance of defeating Cobolli at the ATP Madrid Open tournament.

Additionally, Medvedev has a 53% chance of winning the first set. The simulations also show Cobolli (+1.5) has a 53% chance of covering the games spread, while the under 23.5 games has a 55% chance of hitting, according to our model.

Daniil Medvedev vs. Flavio Cobolli odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

All odds are correct at the time of publication and are subject to change.

Medvedev vs. Cobolli picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: