Duke vs. California prediction: Why Duke is favored to win in college football Week 6, 2025

California and Duke will lock horns in Week 6 college football action at California Memorial Stadium on Saturday, starting at 10:30PM ET.

Based on updated simulation results, Dimers' proven college football model predicts the Duke as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Duke vs. California predictions page.

Duke vs. California prediction: Who will win, cover the spread?

Using powerful machine learning and statistical analysis, we have simulated the result of Duke vs. California 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Duke a 54% chance of beating California. Our predicted final score has Duke winning 27-25.

According to our model, California (+3.5) has a 58% chance of covering the spread, while the over/under total of 54.5 points has a 54% chance of going over.

Duke vs. California odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Duke	California
Spread	-3.5 (+100)	+3.5 (-130)
Moneyline	-154	+140
Total	o54.5 (-115)	u54.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Duke vs. California picks and best bets

Our model's biggest edge in today's Duke vs. California matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Duke vs. California game-day updates and essential details

Saturday's college football game between California and Duke at California Memorial Stadium is scheduled to begin at 10:30PM ET.

• Who: Duke vs. California
• Date: Saturday, October 4, 2025
• Time: 10:30PM ET/7:30PM PT
• Venue: California Memorial Stadium

Dimers' comprehensive preview of Saturday's Duke vs. California matchup includes our prediction, picks and the latest betting odds.

Before making any Duke vs. California picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Duke, with a 54% win probability, will likely beat California on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Duke vs. California insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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