Eastern Michigan vs. Buffalo prediction: Buffalo favored to win in college football Week 6, 2025

Buffalo will square off with Eastern Michigan in Week 6 college football action at UB Stadium on Saturday, commencing at 3:30PM ET.

Based on the latest simulation results, Dimers' proven college football model predicts the Buffalo as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Eastern Michigan vs. Buffalo predictions page.

Eastern Michigan vs. Buffalo prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of Eastern Michigan vs. Buffalo 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Buffalo a 65% chance of defeating Eastern Michigan. Our predicted final score has Buffalo winning 28-22.

According to our model, Eastern Michigan (+9.5) has a 60% chance of covering the spread, while the over/under total of 53.5 points has a 55% chance of going over.

Eastern Michigan vs. Buffalo odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Eastern Michigan	Buffalo
Spread	+9.5 (-110)	-9.5 (-110)
Moneyline	+275	-140
Total	o53.5 (-110)	u53.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Eastern Michigan vs. Buffalo picks and best bets

Our model's strongest edge in today's Eastern Michigan vs. Buffalo matchup is on the total.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Eastern Michigan vs. Buffalo game-day updates and essential details

Saturday's college football action between Buffalo and Eastern Michigan at UB Stadium is scheduled to start at 3:30PM ET.

• Who: Eastern Michigan vs. Buffalo
• Date: Saturday, October 4, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: UB Stadium

Dimers' in-depth preview of Saturday's Eastern Michigan vs. Buffalo matchup includes our prediction, picks and the latest betting odds.

Before making any Eastern Michigan vs. Buffalo picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Buffalo, with a 65% win probability, will likely beat Eastern Michigan on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Eastern Michigan vs. Buffalo insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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