Harvard vs. Holy Cross prediction: Harvard favored to win in college football Week 6, 2025

Holy Cross will face the favored Harvard in Week 6 college football action at Fitton Field on Saturday, starting at 2:00PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts the Harvard as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Harvard vs. Holy Cross predictions page.

Harvard vs. Holy Cross prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the outcome of Harvard vs. Holy Cross 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Harvard an 83% chance of beating Holy Cross. Our predicted final score has Harvard winning 31-17.

According to our model, the bookies have got it right, and Harvard and Holy Cross each have a 50% chance of covering the spread, while the 48.5-point over/under also has an equal 50-50 chance of hitting.

Harvard vs. Holy Cross odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Harvard	Holy Cross
Spread	-14 (-110)	+14 (-110)
Moneyline	-560	+500
Total	o48.5 (-110)	u48.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Harvard vs. Holy Cross picks and best bets

Our model's biggest edge in today's Harvard vs. Holy Cross matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Harvard vs. Holy Cross game-day updates and essential details

Saturday's college football game between Holy Cross and Harvard at Fitton Field is scheduled to start at 2:00PM ET.

• Who: Harvard vs. Holy Cross
• Date: Saturday, October 4, 2025
• Time: 2:00PM ET/11:00AM PT
• Venue: Fitton Field

Dimers' comprehensive preview of Saturday's Harvard vs. Holy Cross matchup includes our prediction, picks and the latest betting odds.

Before making any Harvard vs. Holy Cross picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Harvard, with an 83% win probability, will likely beat Holy Cross on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Harvard vs. Holy Cross insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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