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Illinois State vs. Villanova prediction: Illinois State favored to win in college football Week 17 [2025]

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Written by Mac Douglass

Get Illinois State vs Villanova predictions for college football Saturday.

Illinois State-Villanova Predictions and Game Preview.
Illinois State vs. Villanova college football gameday prediction for Saturday, December 20, 2025.

Villanova and Illinois State will lock horns in Week 17 college football action at Villanova Stadium on Saturday, beginning at 7:30 PM ET.

Based on updated simulations, Dimers' proven college football model gives Illinois State a slight edge with a 52% win probability over Villanova.

This article offers an expanded analysis of Saturday's Illinois State vs. Villanova matchup, including an expanded look at the predicted score, best bets and picks.

Illinois State vs. Villanova prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Illinois State vs. Villanova 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Illinois State a 52% chance of beating Villanova. Our predicted final score has Illinois State winning 25-24.

According to our model, Villanova (+1.5) has a 52% chance of covering the spread, while the over/under total of 50.5 points has a 55% chance of going over.

 

Illinois State vs. Villanova odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type Illinois State Villanova
Spread -1.5 (-105) +1.5 (-115)
Moneyline -105 -105
Total o50.5 (-115) u50.5 (-105)

All odds are correct at the time of publication and are subject to change.

Illinois State vs. Villanova picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread Villanova +1.5 -115
Moneyline Illinois State -105
Total Over 50.5 -115

According to our best college football bets, the top play to make on this game is Over 50.5 total points.

 

Illinois State vs. Villanova game-day updates and essential details

Saturday's college football matchup between Villanova and Illinois State at Villanova Stadium is scheduled to begin at 7:30 PM ET.

  • Who: Illinois State vs. Villanova
  • Date: Saturday, December 20, 2025
  • Time: 7:30 PM ET/4:30PM PT
  • Venue: Villanova Stadium

Conclusion

We predict Illinois State, with a 52% win probability, will likely beat Villanova on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Illinois State vs. Villanova insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Mac Douglass
Senior Editor

Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.

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