Illinois vs. Purdue prediction: Why Illinois is favored to win in college football Week 6, 2025

Purdue and Illinois will clash in Week 6 college football action at Ross-Ade Stadium on Saturday, beginning at 12:00PM ET.

Based on the latest simulation results, Dimers' advanced college football model predicts the Illinois as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Illinois vs. Purdue predictions page.

Illinois vs. Purdue prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of Illinois vs. Purdue 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Illinois a 69% chance of defeating Purdue. Our predicted final score has Illinois winning 31-23.

According to our model, the bookmakers have got it right, and Illinois and Purdue each have a 50% chance of covering the spread, while the over/under total of 54.5 points has a 52% chance of staying under.

Illinois vs. Purdue odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Illinois	Purdue
Spread	-7.5 (-105)	+7.5 (-115)
Moneyline	-295	+250
Total	o54.5 (-106)	u54.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Illinois vs. Purdue picks and best bets

Our model's biggest edge in today's Illinois vs. Purdue matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Illinois vs. Purdue game-day updates and essential details

Saturday's college football action between Purdue and Illinois at Ross-Ade Stadium is scheduled to commence at 12:00PM ET.

• Who: Illinois vs. Purdue
• Date: Saturday, October 4, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Ross-Ade Stadium

Dimers' full preview of Saturday's Illinois vs. Purdue matchup includes our prediction, picks and the latest betting odds.

Before making any Illinois vs. Purdue picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Illinois, with a 69% win probability, will likely beat Purdue on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Illinois vs. Purdue insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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