Indiana State vs. South Dakota State prediction: South Dakota State favored to win in college football Week 10, 2025

South Dakota State and Indiana State will lock horns in Week 10 college football action at Dana J. Dykhouse Stadium on Saturday, beginning at 3:00PM ET.

Based on the latest simulation results, Dimers' proven college football model predicts the South Dakota State as the most likely winner of the Indiana State vs. South Dakota State game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Indiana State vs. South Dakota State prediction: Who will win, cover the spread?

Using innovative machine learning and statistical analysis, we have simulated the result of Indiana State vs. South Dakota State 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives South Dakota State a 98% chance of defeating Indiana State. Our predicted final score has South Dakota State winning 40-10.

According to our model, Indiana State (+30.5) has a 52% chance of covering the spread, while the 53.5-point over/under has a 58% chance of going over.

Indiana State vs. South Dakota State odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Indiana State	South Dakota State
Spread	+30.5 (-110)	-30.5 (-110)
Moneyline	+1700	-10000
Total	o53.5 (-110)	u53.5 (-110)

All odds are correct at the time of publication and are subject to change.

Indiana State vs. South Dakota State picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Indiana State +30.5	-110
Moneyline	South Dakota State	-10000
Total	Over 53.5	-110

According to our best college football bets, the top play to make on this game is Over 53.5 total points.

Indiana State vs. South Dakota State game-day updates and essential details

Saturday's college football matchup between South Dakota State and Indiana State at Dana J. Dykhouse Stadium is scheduled to begin at 3:00PM ET.

• Who: Indiana State vs. South Dakota State
• Date: Saturday, November 1, 2025
• Time: 3:00PM ET/12:00PM PT
• Venue: Dana J. Dykhouse Stadium

Sports betting deal available for NCAAF Saturday

To make the most of Saturday's big day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that unlocks $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict South Dakota State, with a 98% win probability, will likely beat Indiana State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Indiana State vs. South Dakota State insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Keep up with the latest college football betting news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the latest predictions for the national title game and major conferences.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.