Indiana State vs. Southern Illinois prediction: Southern Illinois favored to win in college football Week 6, 2025

Southern Illinois will square off with Indiana State in Week 6 college football action at Saluki Stadium on Saturday, with kickoff at 7:00PM ET.

Based on updated simulations, Dimers' proven college football model predicts the Southern Illinois as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Indiana State vs. Southern Illinois predictions page.

Indiana State vs. Southern Illinois prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of Indiana State vs. Southern Illinois 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Southern Illinois a 92% chance of beating Indiana State. Our predicted final score has Southern Illinois winning 41-17.

According to our model, the bookmakers have got it right, and Indiana State and Southern Illinois each have a 50% chance of covering the spread, while the 58.5-point over/under also has an equal 50-50 chance of hitting.

Indiana State vs. Southern Illinois odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Indiana State	Southern Illinois
Spread	+23.5 (-110)	-23.5 (-110)
Moneyline	+1700	-2500
Total	o58.5 (-110)	u58.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Indiana State vs. Southern Illinois picks and best bets

Our model's strongest edge in today's Indiana State vs. Southern Illinois matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Indiana State vs. Southern Illinois game-day updates and essential details

Saturday's college football action between Southern Illinois and Indiana State at Saluki Stadium is scheduled to start at 7:00PM ET.

• Who: Indiana State vs. Southern Illinois
• Date: Saturday, October 4, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Saluki Stadium

Dimers' in-depth preview of Saturday's Indiana State vs. Southern Illinois matchup includes our prediction, picks and the latest betting odds.

Before making any Indiana State vs. Southern Illinois picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Southern Illinois, with a 92% win probability, will likely beat Indiana State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Indiana State vs. Southern Illinois insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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