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Indiana vs. Ohio State prediction: Ohio State favored to win Big 10 Championship, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Indiana vs Ohio State predictions for college football Saturday.
Ohio State will square off with Indiana in the 2025 Big Ten Championship Game at Lucas Oil Stadium on Saturday, with kickoff at 8:00PM ET.
Based on the latest simulations, Dimers' advanced college football model predicts Ohio State as the most likely winner of the Indiana vs. Ohio State game.
This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Big Ten Football Championship Game prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Indiana vs. Ohio State 10,000 times as part of our college football predictions coverage.
Our independent predictive model gives Ohio State a 64% chance of beating Indiana. Our predicted final score has Ohio State winning 26-21.
According to our model, Ohio State (-3.5) has a 52% chance of covering the spread, while the 45.5-point over/under has a 52% chance of staying under.
Indiana vs. Ohio State odds
We have researched the best college football odds in America for this game, which are listed here:
| Bet Type | Indiana | Ohio State |
|---|---|---|
| Spread | +3.5 (-105) | -3.5 (-110) |
| Moneyline | +155 | -166 |
| Total | o45.5 (-110) | u45.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Indiana vs. Ohio State picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Ohio State -3.5 | -110 |
| Moneyline | Ohio State | -166 |
| Total | Under 45.5 | -110 |
According to our college football best bets, the top play to make on this game is Ohio State to win.
Indiana vs. Ohio State game-day updates and essential details
Saturday's college football action between Ohio State and Indiana at Lucas Oil Stadium is scheduled to start at 8:00PM ET.
- Who: Indiana vs. Ohio State
- Date: Saturday, December 6, 2025
- Time: 8:00PM ET/5:00PM PT
- Venue: Lucas Oil Stadium
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Conclusion
We predict Ohio State, with a 64% win probability, will likely beat Indiana on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Indiana vs. Ohio State insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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