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Indiana vs. Purdue prediction: Why Indiana is favored to win Black Friday College Football matchup, 2025
Get Indiana vs Purdue predictions for college football Friday.

Purdue and Indiana will clash in Week 14 college football action at Ross-Ade Stadium on Friday, starting at 7:30PM ET.
Based on the latest simulations, Dimers' proven college football model projects Indiana as the most likely winner of the Indiana vs. Purdue game.
This article offers an expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and picks.
Indiana vs. Purdue prediction: Who will win and cover?
Using powerful machine learning and data analysis, we have simulated the outcome of Indiana vs. Purdue 10,000 times as part of our college football predictions coverage.
Our independent predictive model gives Indiana a 97% chance of beating Purdue. Our predicted final score has Indiana winning 40-11.
According to our model, the bookmakers have got it right, and Indiana and Purdue each have a 50% chance of covering the spread, while the over/under total of 54.5 points has a 55% chance of going over.
Indiana vs. Purdue odds
We have sourced the best college football odds in America for this game, which are listed here:
| Bet Type | Indiana | Purdue |
|---|---|---|
| Spread | -28.5 (-104) | +28.5 (-115) |
| Moneyline | -5000 | +2200 |
| Total | o54.5 (-104) | u54.5 (-115) |
All odds are correct at the time of publication and are subject to change.
Indiana vs. Purdue picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Indiana -28.5 | -104 |
| Moneyline | Indiana | -5000 |
| Total | Over 54.5 | -104 |
According to our college football best bets, the top play to make on this game is Over 54.5 total points.
Indiana vs. Purdue game-day updates and essential details
Friday's college football game between Purdue and Indiana at Ross-Ade Stadium is scheduled to begin at 7:30PM ET.
- Who: Indiana vs. Purdue
- Date: Friday, November 28, 2025 (Black Friday)
- Time: 7:30PM ET/4:30PM PT
- Venue: Ross-Ade Stadium
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Conclusion
We predict Indiana, with a 97% win probability, will likely beat Purdue on Black Friday.
AI and automation have enhanced this article to quickly deliver accurate Indiana vs. Purdue insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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