Iowa State vs. Cincinnati prediction: Why Cincinnati is favored to win in college football Week 6, 2025

Cincinnati will square off with Iowa State in Week 6 college football action at Nippert Stadium on Saturday, beginning at 12:00PM ET.

Based on updated simulations, Dimers' proven college football model predicts the Cincinnati as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Iowa State vs. Cincinnati predictions page.

Iowa State vs. Cincinnati prediction: Who will win, cover the spread?

Using trusted machine learning and data analysis, we have simulated the outcome of Iowa State vs. Cincinnati 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Cincinnati a 57% chance of defeating Iowa State. Our predicted final score has Cincinnati winning 28-25.

According to our model, Iowa State (+3.5) has a 53% chance of covering the spread, while the over/under total of 61.5 points has a 56% chance of staying under.

Iowa State vs. Cincinnati odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Iowa State	Cincinnati
Spread	+3.5 (-110)	-3.5 (-120)
Moneyline	+154	-125
Total	o61.5 (-118)	u61.5 (-112)

All odds are correct at the time of publication and are subject to change.

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Iowa State vs. Cincinnati picks and best bets

Our model's strongest edge in today's Iowa State vs. Cincinnati matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Iowa State vs. Cincinnati game-day updates and essential details

Saturday's college football action between Cincinnati and Iowa State at Nippert Stadium is scheduled to start at 12:00PM ET.

• Who: Iowa State vs. Cincinnati
• Date: Saturday, October 4, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Nippert Stadium

Dimers' comprehensive preview of Saturday's Iowa State vs. Cincinnati matchup includes our prediction, picks and the latest betting odds.

Before making any Iowa State vs. Cincinnati picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Cincinnati, with a 57% win probability, will likely beat Iowa State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Iowa State vs. Cincinnati insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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