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Kentucky vs. Louisville prediction: Louisville favored to win in college football Week 14, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Kentucky vs Louisville predictions for college football Saturday.
Louisville will square off with Kentucky in Week 14 college football action at L&N Federal Credit Union Stadium on Saturday, with kickoff at 12:00PM ET.
Based on updated simulations, Dimers' advanced college football model predicts Louisville as the most likely winner of the Kentucky vs. Louisville game.
This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Kentucky vs. Louisville prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the result of Kentucky vs. Louisville 10,000 times as part of our college football predictions coverage.
Our leading predictive model gives Louisville a 57% chance of beating Kentucky. Our predicted final score has Louisville winning 24-22.
According to our model, Louisville (-1.5) has a 52% chance of covering the spread, while the 45.5-point over/under has a 52% chance of staying under.
Kentucky vs. Louisville odds
We have researched the best college football odds in America for this game, which are listed here:
| Bet Type | Kentucky | Louisville |
|---|---|---|
| Spread | +1.5 (-120) | -1.5 (+100) |
| Moneyline | -108 | -105 |
| Total | o45.5 (-108) | u45.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Kentucky vs. Louisville picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Louisville -1.5 | +100 |
| Moneyline | Louisville | -105 |
| Total | Under 45.5 | -110 |
According to our college football best bets, the top play to make on this game is Louisville to win.
Kentucky vs. Louisville game-day updates and essential details
Saturday's college football matchup between Louisville and Kentucky at L&N Federal Credit Union Stadium is scheduled to start at 12:00PM ET.
- Who: Kentucky vs. Louisville
- Date: Saturday, November 29, 2025
- Time: 12:00PM ET/9:00AM PT
- Venue: L&N Federal Credit Union Stadium
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Conclusion
We predict Louisville, with a 57% win probability, will likely beat Kentucky on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Kentucky vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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