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Kentucky vs. Louisville prediction: Kentucky favored to win women's college basketball matchup [11/22/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Kentucky vs Louisville predictions for college basketball Saturday.
Women's college basketball action continues on Saturday at 2:00PM ET as Kentucky takes on Louisville at KFC Yum! Center.
Based on the latest simulation results, Dimers' new women's basketball model predicts Kentucky as the most likely winner of the Kentucky vs. Louisville game.
This article offers a closer look at Saturday's matchup, including best bets and picks.
Kentucky vs. Louisville prediction: Who will win?
Using powerful machine learning and data, we have simulated the outcome of Saturday's women's basketball game between Kentucky and Louisville 10,000 times as part of our women's college basketball predictions coverage.
Our leading predictive model currently gives Kentucky a 65% chance of beating Louisville.
According to our model, the 134.5-point over/under has an equal 50-50 chance of hitting.
Kentucky vs. Louisville odds
We have sourced the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | Kentucky | Louisville |
|---|---|---|
| Spread | -4.5 (-110) | +4.5 (-110) |
| Moneyline | -196 | +170 |
| Total | o134.5 (-110) | u134.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Kentucky vs. Louisville picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Louisville +4.5 | -110 |
| Moneyline | Kentucky | -196 |
| Total | Over 134.5 | -110 |
According to our women's college basketball best bets, the top play to make on this game is Kentucky to win.
Kentucky vs. Louisville game-day updates and essential details
Saturday's women's basketball action between Louisville and Kentucky at KFC Yum! Center is scheduled to commence at 2:00PM ET.
- Who: Kentucky vs. Louisville
- Date: Saturday, November 22, 2025
- Time: 2:00PM ET/11:00AM PT
- Venue: KFC Yum! Center
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Conclusion
We predict Kentucky, with a 65% win probability, will likely beat Louisville on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Kentucky vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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