Louisiana-Monroe vs. Northwestern prediction: Northwestern favored to win in college football Week 6, 2025

Northwestern will square off with Louisiana-Monroe in Week 6 college football action at Northwestern Medicine Field at Martin Stadium on Saturday, starting at 3:30PM ET.

Based on updated simulations, Dimers' proven college football model projects the Northwestern as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Louisiana-Monroe vs. Northwestern predictions page.

Louisiana-Monroe vs. Northwestern prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the outcome of Louisiana-Monroe vs. Northwestern 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Northwestern an 80% chance of beating Louisiana-Monroe. Our predicted final score has Northwestern winning 28-17.

According to our model, Louisiana-Monroe (+13.5) has a 53% chance of covering the spread, while the over/under total of 47.5 points has a 61% chance of staying under.

Louisiana-Monroe vs. Northwestern odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Louisiana-Monroe	Northwestern
Spread	+13.5 (-110)	-13.5 (-105)
Moneyline	+410	-280
Total	o47.5 (-110)	u47.5 (-120)

All odds are correct at the time of publication and are subject to change.

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Louisiana-Monroe vs. Northwestern picks and best bets

Our model's strongest edge in today's Louisiana-Monroe vs. Northwestern matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Louisiana-Monroe vs. Northwestern game-day updates and essential details

Saturday's college football action between Northwestern and Louisiana-Monroe at Northwestern Medicine Field at Martin Stadium is scheduled to commence at 3:30PM ET.

• Who: Louisiana-Monroe vs. Northwestern
• Date: Saturday, October 4, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Northwestern Medicine Field at Martin Stadium

Dimers' comprehensive preview of Saturday's Louisiana-Monroe vs. Northwestern matchup includes our prediction, picks and the latest betting odds.

Before making any Louisiana-Monroe vs. Northwestern picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Northwestern, with an 80% win probability, will likely beat Louisiana-Monroe on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Louisiana-Monroe vs. Northwestern insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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