Louisiana-Monroe vs. Southern Miss prediction: Southern Miss favored to win in college football Week 9, 2025

Southern Miss will square off with Louisiana-Monroe in Week 9 college football action at M.M. Roberts Stadium on Saturday, beginning at 3:30PM ET.

Based on the latest simulation results, Dimers' advanced college football model projects the Southern Miss as the most likely winner of the Louisiana-Monroe vs. Southern Miss game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Louisiana-Monroe vs. Southern Miss prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the outcome of Louisiana-Monroe vs. Southern Miss 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Southern Miss an 83% chance of defeating Louisiana-Monroe. Our predicted final score has Southern Miss winning 30-17.

According to our model, the bookmakers have got it right, and Louisiana-Monroe and Southern Miss each have a 50% chance of covering the spread, while the over/under total of 49.5 points also has an equal 50-50 chance of hitting.

Louisiana-Monroe vs. Southern Miss odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Louisiana-Monroe	Southern Miss
Spread	+13.5 (-105)	-13.5 (-115)
Moneyline	+440	-550
Total	o49.5 (-102)	u49.5 (-112)

All odds are correct at the time of publication and are subject to change.

Louisiana-Monroe vs. Southern Miss picks and best bet

Our predictions, matched with the listed odds, reveal the top betting picks for this game, detailed in our best college football bets, crafted from expert modeling and analysis:

Bet Type	Pick	Bet Now
Spread	Louisiana-Monroe +13.5	-105
Moneyline	Louisiana-Monroe	+440
Total	Over 49.5	-102

According to our college football best bets, the top play to make on this game is Over 49.5 total points.

Louisiana-Monroe vs. Southern Miss game-day updates and essential details

Saturday's college football matchup between Southern Miss and Louisiana-Monroe at M.M. Roberts Stadium is scheduled to begin at 3:30PM ET.

• Who: Louisiana-Monroe vs. Southern Miss
• Date: Saturday, October 25, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: M.M. Roberts Stadium

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Conclusion

We predict Southern Miss, with an 83% win probability, will likely beat Louisiana-Monroe on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Louisiana-Monroe vs. Southern Miss insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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