Miami Ohio vs. Northern Illinois prediction: Miami Ohio favored to win in college football Week 6, 2025

Northern Illinois and Miami Ohio will meet in Week 6 college football action at Brigham Field at Huskie Stadium on Saturday, starting at 3:30PM ET.

Based on updated simulation results, Dimers' advanced college football model predicts the Miami Ohio as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Miami Ohio vs. Northern Illinois predictions page.

Miami Ohio vs. Northern Illinois prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of Miami Ohio vs. Northern Illinois 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Miami Ohio a 66% chance of beating Northern Illinois. Our predicted final score has Miami Ohio winning 21-16.

According to our model, the bookies have got it right, and Miami Ohio and Northern Illinois each have a 50% chance of covering the spread, while the 38.5-point over/under has a 52% chance of staying under.

Miami Ohio vs. Northern Illinois odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Miami Ohio	Northern Illinois
Spread	-4.5 (-110)	+4.5 (-105)
Moneyline	-192	+168
Total	o38.5 (-105)	u38.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Miami Ohio vs. Northern Illinois picks and best bets

Our model's biggest edge in today's Miami Ohio vs. Northern Illinois matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Miami Ohio vs. Northern Illinois game-day updates and essential details

Saturday's college football matchup between Northern Illinois and Miami Ohio at Brigham Field at Huskie Stadium is scheduled to begin at 3:30PM ET.

• Who: Miami Ohio vs. Northern Illinois
• Date: Saturday, October 4, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Brigham Field at Huskie Stadium

Dimers' comprehensive preview of Saturday's Miami Ohio vs. Northern Illinois matchup includes our prediction, picks and the latest betting odds.

Before making any Miami Ohio vs. Northern Illinois picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Miami Ohio, with a 66% win probability, will likely beat Northern Illinois on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Miami Ohio vs. Northern Illinois insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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