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Michigan State vs. Iowa prediction: Why Iowa is favored to win in college football Week 13, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Michigan State vs Iowa predictions for college football Saturday.
Iowa will square off with Michigan State in Week 13 college football action at Kinnick Stadium on Saturday, commencing at 3:30PM ET.
Based on updated simulation results, Dimers' proven college football model projects Iowa as the most likely winner of the Michigan State vs. Iowa game.
This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Michigan State vs. Iowa prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Michigan State vs. Iowa 10,000 times as part of our college football predictions coverage.
Our leading predictive model currently gives Iowa a 91% chance of beating Michigan State. Our predicted final score has Iowa winning 31-13.
According to our model, the bookmakers have got it right, and Michigan State and Iowa each have a 50% chance of covering the spread, while the over/under total of 42.5 points has a 58% chance of staying under.
Michigan State vs. Iowa odds
We have researched the best College Football odds in America for this game, which are listed here:
| Bet Type | Michigan State | Iowa |
|---|---|---|
| Spread | +17.5 (-105) | -17.5 (-102) |
| Moneyline | +730 | -850 |
| Total | o42.5 (-110) | u42.5 (-108) |
All odds are correct at the time of publication and are subject to change.
Michigan State vs. Iowa picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Iowa -17.5 | -102 |
| Moneyline | Iowa | -850 |
| Total | Under 42.5 | -108 |
According to our college football best bets, the top play to make on this game is Under 42.5 total points.
Michigan State vs. Iowa game-day updates and essential details
Saturday's college football action between Iowa and Michigan State at Kinnick Stadium is scheduled to begin at 3:30PM ET.
- Who: Michigan State vs. Iowa
- Date: Saturday, November 22, 2025
- Time: 3:30PM ET/12:30PM PT
- Venue: Kinnick Stadium
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Conclusion
We predict Iowa, with a 91% win probability, will likely beat Michigan State on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Michigan State vs. Iowa insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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