Michigan State vs. Nebraska prediction: Nebraska favored to win in college football Week 6, 2025

Nebraska will face Michigan State in Week 6 college football action at Memorial Stadium on Saturday, starting at 4:00PM ET.

Based on updated simulation results, Dimers' proven college football model predicts the Nebraska as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Michigan State vs. Nebraska predictions page.

Michigan State vs. Nebraska prediction: Who will win, cover the spread?

Using powerful machine learning and data analysis, we have simulated the outcome of Michigan State vs. Nebraska 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Nebraska an 81% chance of defeating Michigan State. Our predicted final score has Nebraska winning 32-19.

According to our model, the bookies have got it right, and Michigan State and Nebraska each have a 50% chance of covering the spread, while the over/under total of 48.5 points has a 58% chance of staying under.

Michigan State vs. Nebraska odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Michigan State	Nebraska
Spread	+13.5 (-115)	-13.5 (-105)
Moneyline	+450	-500
Total	o48.5 (-110)	u48.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Michigan State vs. Nebraska picks and best bets

Our model's strongest edge in today's Michigan State vs. Nebraska matchup is on the spread.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Michigan State vs. Nebraska game-day updates and essential details

Saturday's college football game between Nebraska and Michigan State at Memorial Stadium is scheduled to start at 4:00PM ET.

• Who: Michigan State vs. Nebraska
• Date: Saturday, October 4, 2025
• Time: 4:00PM ET/1:00PM PT
• Venue: Memorial Stadium

Dimers' in-depth preview of Saturday's Michigan State vs. Nebraska matchup includes our prediction, picks and the latest betting odds.

Before making any Michigan State vs. Nebraska picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Nebraska, with an 81% win probability, will likely beat Michigan State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Michigan State vs. Nebraska insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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