Ole Miss vs. Oklahoma prediction: Oklahoma favored to win in college football Week 9, 2025

Oklahoma and Mississippi will clash in Week 9 college football action at Gaylord Family Oklahoma Memorial Stadium on Saturday, commencing at 12:00PM ET.

Based on updated simulations, Dimers' advanced college football model predicts the Oklahoma as the most likely winner of the Ole Miss vs. Oklahoma game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Ole Miss vs. Oklahoma prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of Ole Miss vs. Oklahoma 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Oklahoma a 56% chance of defeating Mississippi. Our predicted final score has Oklahoma winning 27-25.

According to our model, Mississippi (+4.5) has a 59% chance of covering the spread, while the 52.5-point over/under has an equal 50-50 chance of hitting.

Ole Miss vs. Oklahoma odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Ole Miss	Oklahoma
Spread	+4.5 (-105)	-4.5 (-105)
Moneyline	+165	-174
Total	o52.5 (-105)	u52.5 (-110)

All odds are correct at the time of publication and are subject to change.

Ole Miss vs. Oklahoma picks and best bet

Our probabilities, matched with the listed odds, reveal the top betting picks for this game, detailed in Dimers' college football best bets, crafted from expert modeling and analysis:

Bet Type	Pick	Bet Now
Spread	Mississippi +4.5	-105
Moneyline	Mississippi	+165
Total	Over 52.5	-105

According to our best college football bets, the top play to make on this game is Mississippi +4.5 at the spread.

Ole Miss vs. Oklahoma game-day updates and essential details

Saturday's college football game between Oklahoma and Ole Miss at Gaylord Family Oklahoma Memorial Stadium is scheduled to commence at 12:00PM ET.

• Who: Mississippi vs. Oklahoma
• Date: Saturday, October 25, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Gaylord Family Oklahoma Memorial Stadium

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Conclusion

We predict Oklahoma, with a 56% win probability, will likely beat Mississippi on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Mississippi vs. Oklahoma insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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