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MLB picks today: Tuesday's MLB best bets include two over/under plays [9/23/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get MLB picks today and best bets for Tuesday, September 23, 2025.
Today's MLB picks for September 23, 2025 are here, with Tuesday’s MLB best bets built on thousands of predictive simulations analyzing the latest odds and matchups.
These MLB best bets include matchups like Brewers vs. Padres and Rockies vs. Mariners, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.
But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge MLB bets—the ones with true long-term value—join Dimers Pro.
Pro members get unlimited access to everything Dimers has to offer on Tuesday, September 23, 2025, including our full set of picks and best bets for today and the week ahead.
List of MLB best bets tonight [9/23, updated 9:33PM ET]
After digging deep into the numbers and conducting thousands of simulations, our famous predictive analytics model has figured out the best baseball bets for Tuesday, September 23, 2025.
Padres +1.5 (-152)
- Probability: 62.8%
- Edge: 2.5%
- Matchup: Brewers vs. Padres (9:40PM ET, Tuesday)
Our model has pinpointed a high-probability MLB betting opportunity tonight, which comes in the Brewers vs. Padres matchup. We recommend a run line bet on Padres +1.5 at -152 odds, with our analysis showing a 62.8% chance of hitting and a compelling edge of 2.5%.
Rockies vs. Mariners over 8 runs (-110)
- Probability: 57.6%
- Edge: 5.2%
- Matchup: Rockies vs. Mariners (9:40PM ET, Tuesday)
Our model has found another strong MLB bet for Tuesday's baseball action, this time in the matchup between the Rockies and Mariners. We suggest placing an over/under wager on over 8 runs at -110 odds, with a 57.6% probability delivering a 5.2% edge.
Brewers vs. Padres over 8 runs (-110)
- Probability: 57.2%
- Edge: 4.8%
- Matchup: Brewers vs. Padres (9:40PM ET, Tuesday)
Our model has found another strong MLB bet for Tuesday's baseball action, this time in the Brewers vs. Padres game. We recommend an over/under bet on over 8 runs at -110 odds. Our projections shows a 57.2% probability and 4.8% edge for this wager.
MLB best bets: Tuesday, 9/23/2025
As of 9:33PM ET, here are our top three MLB bets by probability recommended by our model:
| Matchup | Bet | Odds | Probability | Edge |
|---|---|---|---|---|
| Brewers vs. Padres | Padres +1.5 | -152 @ FanDuel | 62.8% | 2.5% |
| Rockies vs. Mariners | Over 8 Runs | -110 @ FanDuel | 57.6% | 5.2% |
| Brewers vs. Padres | Over 8 Runs | -110 @ FanDuel | 57.2% | 4.8% |
The bets listed here are sorted by win probability—but the real path to profit lies in high-edge plays. Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.
Among today's MLB picks is a +170 run line bet with a 9.5% edge—the kind of high-upside play that makes a difference over time.
List of upcoming MLB games to bet on [9/23/2025]
- Royals vs. Angels (9:38PM ET, Tuesday)
- Dodgers vs. D-Backs (9:40PM ET, Tuesday)
- Brewers vs. Padres (9:40PM ET, Tuesday)
- Rockies vs. Mariners (9:40PM ET, Tuesday)
- Cardinals vs. Giants (9:45PM ET, Tuesday)
- Astros vs. Athletics (10:05PM ET, Tuesday)
- Nationals vs. Braves (12:15PM ET, Wednesday)
- Rays vs. Orioles (6:35PM ET, Wednesday)
- Pirates vs. Reds (6:40PM ET, Wednesday)
- Tigers vs. Guardians (6:40PM ET, Wednesday)
- Marlins vs. Phillies (6:45PM ET, Wednesday)
- Red Sox vs. Blue Jays (7:07PM ET, Wednesday)
- Mets vs. Cubs (8:05PM ET, Wednesday)
More about MLB
The bets on this page form part of our MLB player props and MLB best bets series.
For more MLB betting content, we have MLB trends for every game, as well as daily MLB betting news and the latest World Series odds and predictions.
Conclusion
Our MLB best bets are locked and loaded for September 23, 2025, featuring plays such as Padres +1.5 and over 8 runs in the Rockies vs. Mariners matchup. Powered by advanced simulations, these picks are here to boost your betting game.
This article, enhanced by AI and automation, aims to deliver accurate MLB insights quickly, with human oversight ensuring high editorial quality. Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
All odds and probabilities in this article are correct and accurate at the time of publication.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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