MLB picks today: Wednesday's MLB best bets include Padres vs. Braves play [7/22/2026]
Get MLB picks today and best bets for Wednesday, July 22, 2026.
Today’s MLB picks for July 22, 2026 are here, with Padres vs. Braves and Athletics vs. Diamondbacks among the top plays identified by our model across Wednesday’s MLB slate.
Dimers’ predictive analytics engine runs 24/7, scanning the latest baseball odds to uncover top betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of MLB best bets today [7/22, updated 1:13AM ET]
Below, you’ll find today’s top 10 baseball bets, ranked by edge for Wednesday, July 22, 2026.
Padres -1.5 (+165)
- Edge: 6.7%
- Probability: 44.4%
- Matchup: Padres vs. Braves (7:15PM ET)
Our model has identified value on Padres -1.5 at +165 odds. A 44.4% probability produces an edge of 6.7%, making this the strongest play for today's MLB slate.
Athletics vs. Diamondbacks Over 9.5 runs (+117)
- Edge: 6.2%
- Probability: 52.3%
- Matchup: Athletics vs. Diamondbacks (3:40PM ET)
Athletics vs. Diamondbacks over 9.5 runs carries a 6.2% edge and a probability of 52.3% at +117 odds, according to our model.
Twins vs. Guardians Over 8.5 runs (+113)
- Edge: 5.7%
- Probability: 52.7%
- Matchup: Twins vs. Guardians (6:40PM ET)
Twins vs. Guardians Over 8.5 runs at +113 odds shows a 5.7% edge, supported by a 52.7% probability in simulations.
Marlins -1.5 (+174)
- Edge: 5.7%
- Probability: 42.2%
- Matchup: Marlins vs. Astros (8:10PM ET)
A 5.7% edge and 42.2% probability makes Marlins -1.5 vs. Astros a value play in the Marlins vs. Astros matchup, per our model.
Rockies ML (+122)
- Edge: 5.6%
- Probability: 50.7%
- Matchup: Nationals vs. Rockies (3:10PM ET)
Rockies ML at +122 odds presents a 5.6% edge, with simulations resulting in a probability of 50.7%.
Orioles vs. Red Sox Over 9 runs (+100)
- Edge: 5.4%
- Probability: 55.4%
- Matchup: Orioles vs. Red Sox (7:10PM ET)
Our model finds value on Over 9 runs in Orioles vs. Red Sox at +100 odds, supported by an edge of 5.4%.
Rockies +1.5 (-122)
- Edge: 5.4%
- Probability: 60.4%
- Matchup: Nationals vs. Rockies (3:10PM ET)
Our model has uncovered value on Rockies +1.5 at -122 odds. A 60.4% probability produces a 5.4% edge, making this a strong play for today's MLB action.
Mets ML (+133)
- Edge: 4.4%
- Probability: 47.3%
- Matchup: Mets vs. Brewers (2:10PM ET)
A 4.4% edge on a 47.3% probability makes Mets to win at +133 odds a solid value play in today's Mets vs. Brewers matchup.
White Sox vs. RangersOver 8.5 runs (-111)
- Edge: 4.0%
- Probability: 56.6%
- Matchup: White Sox vs. Rangers (8:05PM ET)
Our model projects value on Over 8.5 runs at -111 odds. A 56.6% probability produces a 4.0% edge, making the Over the favorable side in today's matchup.
Tigers vs. Cubs Over 7.5 runs (-117)
- Edge: 3.9%
- Probability: 57.8%
- Matchup: Tigers vs. Cubs (8:10PM ET)
Rounding out our top 10 bets, Tigers vs. Cubs Over 7.5 runs at -117 odds shows a 57.8% probability and a 3.9% edge.
MLB best bets summary: Wednesday, 7/22/2026
As of 1:13AM ET, here are our top MLB bets by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| Padres vs. Braves | Padres -1.5 | +165 @ BetMGM | 6.7% | 44.4% |
| Athletics vs. Diamondbacks | Over 9.5 runs | +117 @ Polymarket | 6.2% | 52.3% |
| Twins vs. Guardians | Over 8.5 Runs | +113 @ Polymarket | 5.7% | 52.7% |
| Marlins vs. Astros | Marlins -1.5 vs. Astros | +174 @ Novig | 5.7% | 42.2% |
| Nationals vs. Rockies | Rockies ML | +122 @ Novig | 5.6% | 50.7% |
| Orioles vs. Red Sox | Over 9 Runs | +100 @ BetMGM | 5.4% | 55.4% |
| Nationals vs. Rockies | Rockies +1.5 | -122 @ Novig | 5.4% | 60.4% |
| Mets vs. Brewers | Mets ML | +133 @ Novig | 4.4% | 47.3% |
| White Sox vs. Rangers | Over 8.5 Runs | -111 @ Novig | 4.0% | 56.6% |
| Tigers vs. Cubs | Over 7.5 Runs | -117 @ Novig | 3.9% | 57.8% |
List of upcoming MLB games to bet on [7/22/2026]
- Pirates vs. Yankees (1:35PM ET, Wednesday)
- Giants vs. Royals (2:10PM ET, Wednesday)
- Mets vs. Brewers (2:10PM ET, Wednesday)
- Nationals vs. Rockies (3:10PM ET, Wednesday)
- Reds vs. Mariners (3:40PM ET, Wednesday)
- Athletics vs. D-Backs (3:40PM ET, Wednesday)
- Cardinals vs. Angels (4:07PM ET, Wednesday)
- Twins vs. Guardians (6:40PM ET, Wednesday)
- Dodgers vs. Phillies (6:40PM ET, Wednesday)
- Rays vs. Blue Jays (7:07PM ET, Wednesday)
- Orioles vs. Red Sox (7:10PM ET, Wednesday)
- Padres vs. Braves (7:15PM ET, Wednesday)
- White Sox vs. Rangers (8:05PM ET, Wednesday)
- Tigers vs. Cubs (8:10PM ET, Wednesday)
- Marlins vs. Astros (8:10PM ET, Wednesday)
Conclusion
Our MLB best bets are locked and loaded for July 22, 2026, featuring plays such as Padres -1.5 vs. Braves and over 9.5 runs in the Athletics vs. Diamondbacks matchup. Powered by advanced simulations, these picks are here to boost your betting game.
Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.
All odds and probabilities in this article are correct and accurate at the time of publication.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
