Murray State vs. South Dakota prediction: South Dakota favored to win in college football Week 6, 2025

South Dakota will square off with Murray State in Week 6 college football action at The DakotaDome on Saturday, with kickoff at 3:00PM ET.

Based on the latest simulation results, Dimers' advanced college football model predicts the South Dakota as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Murray State vs. South Dakota predictions page.

Murray State vs. South Dakota prediction: Who will win, cover the spread?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Murray State vs. South Dakota 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives South Dakota a 95% chance of defeating Murray State. Our predicted final score has South Dakota winning 41-13.

According to our model, the bookmakers have got it right, and Murray State and South Dakota each have a 50% chance of covering the spread, while the over/under total of 56.5 points has a 52% chance of going over.

Murray State vs. South Dakota odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Murray State	South Dakota
Spread	+27.5 (-110)	-27.5 (-110)
Moneyline	+3000	-5999
Total	o56.5 (-110)	u56.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Murray State vs. South Dakota picks and best bets

Our model's biggest edge in today's Murray State vs. South Dakota matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Murray State vs. South Dakota game-day updates and essential details

Saturday's college football game between South Dakota and Murray State at The DakotaDome is scheduled to start at 3:00PM ET.

• Who: Murray State vs. South Dakota
• Date: Saturday, October 4, 2025
• Time: 3:00PM ET/12:00PM PT
• Venue: The DakotaDome

Dimers' comprehensive preview of Saturday's Murray State vs. South Dakota matchup includes our prediction, picks and the latest betting odds.

Before making any Murray State vs. South Dakota picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict South Dakota, with a 95% win probability, will likely beat Murray State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Murray State vs. South Dakota insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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