North Dakota vs. South Dakota prediction: North Dakota favored to win in college football Week 10, 2025

South Dakota and North Dakota will meet in Week 10 college football action at The DakotaDome on Saturday, commencing at 2:00PM ET.

Based on updated simulations, Dimers' advanced college football model predicts the North Dakota as the most likely winner of the North Dakota vs. South Dakota game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

North Dakota vs. South Dakota prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of North Dakota vs. South Dakota 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives North Dakota a 79% chance of defeating South Dakota. Our predicted final score has North Dakota winning 31-19.

According to our model, South Dakota (+12.5) has a 52% chance of covering the spread, while the over/under total of 51.5 points has a 53% chance of going over.

North Dakota vs. South Dakota odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	North Dakota	South Dakota
Spread	-12.5 (-110)	+12.5 (-108)
Moneyline	-400	+350
Total	o51.5 (-110)	u51.5 (-110)

All odds are correct at the time of publication and are subject to change.

North Dakota vs. South Dakota picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	South Dakota +12.5	-108
Moneyline	North Dakota	-400
Total	Over 51.5	-110

According to our college football best bets, the top play to make on this game is Over 51.5 total points.

North Dakota vs. South Dakota game-day updates and essential details

Saturday's college football matchup between South Dakota and North Dakota at The DakotaDome is scheduled to commence at 2:00PM ET.

• Who: North Dakota vs. South Dakota
• Date: Saturday, November 1, 2025
• Time: 2:00PM ET/11:00AM PT
• Venue: The DakotaDome

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Conclusion

We predict North Dakota, with a 79% win probability, will likely beat South Dakota on Saturday.

AI and automation have enhanced this article to quickly deliver accurate North Dakota vs. South Dakota insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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