Novak Djokovic vs. Carlos Alcaraz prediction, odds, picks for US Open 2025

Novak Djokovic will square off with Carlos Alcaraz in the semifinals of the US Open Men's Singles 2025 on Friday.

Based on updated simulation results, Dimers' proven tennis model predicts Carlos Alcaraz as the most likely winner of the match.

For a closer look at Friday's match, including best bets and picks, visit our interactive Djokovic vs. Alcaraz predictions page.

Djokovic vs. Alcaraz prediction: Who will win and advance to the final?

Using powerful machine learning and data, we have simulated the result of Friday's Djokovic-Alcaraz men's singles match 10,000 times as part of our tennis predictions coverage.

Our independent predictive model currently gives Alcaraz a 77% chance of winning against Djokovic in the US Open 2025.

Additionally, Alcaraz has a 70% chance of winning the first set, while the under 39.5 games has a 65% chance of hitting, according to our model.

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Novak Djokovic vs. Carlos Alcaraz odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

Bet Type	Djokovic	Alcaraz
Moneyline	+300	-350
First Set	+175	-227
Total Games	o39.5 (-110)	u39.5 (-130)

All odds are correct at the time of publication and are subject to change.

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Djokovic vs. Alcaraz picks and best bets

Our model's biggest edge in today's Djokovic vs. Alcaraz match is on the first set.

Our expert predictions, aligned with the current odds, reveal the best tennis picks and tennis best bets for every match throughout the year.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Djokovic vs. Alcaraz updates and essential details

The US Open 2025 match between Novak Djokovic and Carlos Alcaraz is scheduled to begin on Friday at 3:00PM ET.

• Who: Novak Djokovic vs. Carlos Alcaraz
• Date: Friday, September 5, 2025
• Approx. Time: 3:00PM ET/12:00PM PT
• Tournament: US Open Men's Singles 2025
• Round: Semifinals

All dates and times in this article are United States Eastern Time unless otherwise stated.

Dimers.com's in-depth preview of Friday's Djokovic vs. Alcaraz match includes our prediction, picks and the latest betting odds.

Before making any Novak Djokovic vs. Carlos Alcaraz picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

Key tennis betting guides and insights

• Learn how to bet on tennis and understand how tennis odds work
• Explore where sports odds come from and how they’re applied to tennis matches
• Stay informed with guides on where online sports betting is currently legal and which states could legalize next
• Improve your chances with proven sports betting strategies that apply to tennis and more

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Conclusion

We predict Carlos Alcaraz, with a 77% win probability, will likely beat Novak Djokovic at the US Open 2025.

AI and automation have enhanced this article to quickly deliver accurate Djokovic vs. Alcaraz insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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