Ohio State vs. Illinois prediction: Why Ohio State is favored to win in college football Week 7, 2025

Illinois and Ohio State will clash in Week 7 college football action at Gies Memorial Stadium on Saturday, with kickoff at 12:00PM ET.

Based on updated simulations, Dimers' proven college football model predicts the Ohio State as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Ohio State vs. Illinois predictions page.

Ohio State vs. Illinois prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the outcome of Ohio State vs. Illinois 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Ohio State an 83% chance of defeating Illinois. Our predicted final score has Ohio State winning 33-19.

According to our model, the bookmakers have got it right, and Ohio State and Illinois each have a 50% chance of covering the spread, while the over/under total of 51.5 points has a 53% chance of staying under.

Ohio State vs. Illinois odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Ohio State	Illinois
Spread	-14.5 (-110)	+14.5 (-110)
Moneyline	-700	+525
Total	o51.5 (-110)	u51.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Ohio State vs. Illinois picks and best bets

Our model's biggest edge in today's Ohio State vs. Illinois matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Ohio State vs. Illinois game-day updates and essential details

Saturday's college football matchup between Illinois and Ohio State at Gies Memorial Stadium is scheduled to commence at 12:00PM ET.

• Who: Ohio State vs. Illinois
• Date: Saturday, October 11, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Gies Memorial Stadium

Dimers' full preview of Saturday's Ohio State vs. Illinois matchup includes our prediction, picks and the latest betting odds.

Before making any Ohio State vs. Illinois picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Ohio State, with an 83% win probability, will likely beat Illinois on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Ohio State vs. Illinois insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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More on college football

Stay informed with the latest college football betting news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the latest probabilities for the national title game and major conferences.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.