Old Dominion vs. Louisiana-Monroe prediction: Old Dominion favored to win in college football Week 10, 2025

Louisiana-Monroe will face the favored Old Dominion in Week 10 college football action at JPS Field at Malone Stadium on Saturday, with kickoff at 3:30PM ET.

Based on updated simulation results, Dimers' proven college football model predicts the Old Dominion as the most likely winner of the Old Dominion vs. Louisiana-Monroe game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Old Dominion vs. Louisiana-Monroe prediction: Who will win, cover the spread?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Old Dominion vs. Louisiana-Monroe 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Old Dominion an 86% chance of beating Louisiana-Monroe. Our predicted final score has Old Dominion winning 35-18.

According to our model, the bookies have got it right, and Old Dominion and Louisiana-Monroe each have a 50% chance of covering the spread, while the over/under total of 55.5 points has a 54% chance of going over.

Old Dominion vs. Louisiana-Monroe odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Old Dominion	Louisiana-Monroe
Spread	-16.5 (-112)	+16.5 (-104)
Moneyline	-800	+570
Total	o55.5 (-105)	u55.5 (-110)

All odds are correct at the time of publication and are subject to change.

Old Dominion vs. Louisiana-Monroe picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Louisiana-Monroe +16.5	-104
Moneyline	Louisiana-Monroe	+570
Total	Over 55.5	-105

According to our college football best bets, the top play to make on this game is Over 55.5 total points.

Old Dominion vs. Louisiana-Monroe game-day updates and essential details

Saturday's college football matchup between Louisiana-Monroe and Old Dominion at JPS Field at Malone Stadium is scheduled to start at 3:30PM ET.

• Who: Old Dominion vs. Louisiana-Monroe
• Date: Saturday, November 1, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: JPS Field at Malone Stadium

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Conclusion

We predict Old Dominion, with an 86% win probability, will likely beat Louisiana-Monroe on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Old Dominion vs. Louisiana-Monroe insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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