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Penn State vs. Michigan State prediction: Why Penn State is favored to win in college football Week 12, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Penn State vs Michigan State predictions for college football Saturday.
Michigan State and Penn State will meet in Week 12 college football action at Spartan Stadium on Saturday, beginning at 3:30PM ET.
Based on updated simulation results, Dimers' advanced college football model predicts Penn State as the most likely winner of the Penn State vs. Michigan State game.
This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Penn State vs. Michigan State prediction: Who will win and cover?
Using innovative machine learning and statistical analysis, we have simulated the outcome of Penn State vs. Michigan State 10,000 times as part of our college football predictions coverage.
Our independent predictive model gives Penn State a 70% chance of defeating Michigan State. Our predicted final score has Penn State winning 27-20.
According to our model, Michigan State (+7) has a 53% chance of covering the spread, while the 48.5-point over/under has a 52% chance of going over.
Penn State vs. Michigan State odds
We have researched the best College Football odds in America for this game, which are listed here:
| Bet Type | Penn State | Michigan State |
|---|---|---|
| Spread | -7 (-112) | +7 (-108) |
| Moneyline | -258 | +225 |
| Total | o48.5 (-115) | u48.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Penn State vs. Michigan State picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Michigan State +7 | -108 |
| Moneyline | Michigan State | +225 |
| Total | Over 48.5 | -115 |
According to our college football best bets, the top play to make on this game is Michigan State +7 at the spread.
Penn State vs. Michigan State game-day updates and essential details
Saturday's college football action between Michigan State and Penn State at Spartan Stadium is scheduled to start at 3:30PM ET.
- Who: Penn State vs. Michigan State
- Date: Saturday, November 15, 2025
- Time: 3:30PM ET/12:30PM PT
- Venue: Spartan Stadium
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Conclusion
We predict Penn State, with a 70% win probability, will likely beat Michigan State on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Penn State vs. Michigan State insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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