Penn State vs. UCLA prediction: Penn State favored to win in college football Week 6, 2025

UCLA will face the favored Penn State in Week 6 college football action at Rose Bowl on Saturday, commencing at 3:30PM ET.

Based on updated simulations, Dimers' proven college football model projects the Penn State as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Penn State vs. UCLA predictions page.

Penn State vs. UCLA prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the outcome of Penn State vs. UCLA 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Penn State a 94% chance of defeating UCLA. Our predicted final score has Penn State winning 34-12.

According to our model, Penn State (-14.5) has a 60% chance of covering the spread, while the over/under total of 51.5 points has a 55% chance of staying under.

Penn State vs. UCLA odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Penn State	UCLA
Spread	-14.5 (-115)	+14.5 (-115)
Moneyline	-660	+1300
Total	o51.5 (-120)	u51.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Penn State vs. UCLA picks and best bets

Our model's strongest edge in today's Penn State vs. UCLA matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Penn State vs. UCLA game-day updates and essential details

Saturday's college football matchup between UCLA and Penn State at Rose Bowl is scheduled to begin at 3:30PM ET.

• Who: Penn State vs. UCLA
• Date: Saturday, October 4, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Rose Bowl

Dimers' comprehensive preview of Saturday's Penn State vs. UCLA matchup includes our prediction, picks and the latest betting odds.

Before making any Penn State vs. UCLA picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Penn State, with a 94% win probability, will likely beat UCLA on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Penn State vs. UCLA insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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