NHL- More Betting
Sabres vs. Penguins Predictions and Odds - Nov 16, 2021

The Pittsburgh Penguins and Buffalo Sabres clash in the NHL at PPG Paints Arena on Tuesday, starting at 7:00 PM EST.
Dimers' best betting picks for Sabres vs. Penguins, plus game predictions and best odds, are detailed below.
Who will win Sabres vs. Penguins?
Using advanced computer power and data, Dimers.com has simulated Tuesday's Sabres-Penguins game 10,000 times.
Dimers' revolutionary predictive analytics model, DimersBOT, gives the Penguins a 68% chance of getting the W against the Sabres.
MORE: Full betting guide for Sabres vs. Penguins
Sabres vs. Penguins Puck Line, Moneyline and Over/Under
The Penguins are -1.5 favorites against the Sabres, with +100 at BetMGM the best odds available.
For the underdog Sabres (+1.5) to cover the puck line, Caesars Sportsbook has the best odds on offer at -115.
FanDuel Sportsbook has the best moneyline odds for the Penguins at -245, which means you can risk $245 to win $100, for a total payout of $345, if they get the W.
Meanwhile, DraftKings Sportsbook has the best moneyline odds for the Sabres at +205, where you can put down $100 to profit $205, earning a total payout of $305, if they win.
The Over/Under for total goals scored is set at 6 with DraftKings Sportsbook, which has the best odds for the Over at +100, while BetMGM has the best odds for the Under at -115.
As always, make sure you check all the legal sportbooks that are available in your state for the best NHL odds and lines.
According to DimersBOT, the Sabres (+1.5) are a 55% chance of covering the puck line, while the Over/Under total of 6 goals is considered an equal 50-50 chance of hitting.
Best Bets for Sabres vs. Penguins
- Puck Line: Sabres +1.5 at -115 with Caesars Sportsbook (55% probability)
- Moneyline: Sabres Win at +205 with DraftKings Sportsbook
- Over/Under: Over 6 at +100 with DraftKings Sportsbook (50% probability)
While the Penguins are more likely to win the game, according to DimersBOT, taking the Sabres moneyline is the best option because of the edge found when comparing our data-led probabilities to the sportsbooks' odds.
Taking advantage of the edges published on Dimers.com is pivotal to being a profitable bettor in the long run.
MORE: Best bets today for all major sports
Sabres vs. Penguins Full Coverage
Dimers has full coverage of Tuesday's Sabres-Penguins game, including pre-game predictions, free picks, and live updates.
Don't forget, DimersBOT updates frequently, so refresh this article for the latest ahead of Sabres vs. Penguins on Tuesday November 16, 2021.
Sabres vs. Penguins 2021 Game Info
When do the Penguins play the Sabres?
- Date: Tuesday November 16, 2021
- Time: 7:00 PM EST / 4:00 PM PST
- Venue: PPG Paints Arena
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