Samford vs. Mercer prediction: Why Mercer is favored to win in college football Week 6, 2025

Mercer will take on Samford in Week 6 college football action at Five Star Stadium on Saturday, beginning at 4:00PM ET.

Based on updated simulation results, Dimers' advanced college football model predicts the Mercer as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Samford vs. Mercer predictions page.

Samford vs. Mercer prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the outcome of Samford vs. Mercer 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Mercer a 93% chance of beating Samford. Our predicted final score has Mercer winning 37-15.

According to our model, Samford (+23.5) has a 52% chance of covering the spread, while the 54.5-point over/under has a 52% chance of going over.

Samford vs. Mercer odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Samford	Mercer
Spread	+23.5 (-110)	-23.5 (-110)
Moneyline	+1500	-2800
Total	o54.5 (-110)	u54.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Samford vs. Mercer picks and best bets

Our model's strongest edge in today's Samford vs. Mercer matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Samford vs. Mercer game-day updates and essential details

Saturday's college football game between Mercer and Samford at Five Star Stadium is scheduled to begin at 4:00PM ET.

• Who: Samford vs. Mercer
• Date: Saturday, October 4, 2025
• Time: 4:00PM ET/1:00PM PT
• Venue: Five Star Stadium

Dimers' in-depth preview of Saturday's Samford vs. Mercer matchup includes our prediction, picks and the latest betting odds.

Before making any Samford vs. Mercer picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Mercer, with a 93% win probability, will likely beat Samford on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Samford vs. Mercer insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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