South Carolina vs. Louisville prediction: South Carolina favored to win women's college basketball matchup [12/4/2025]

Louisville will take on the favored South Carolina in women's college basketball action at KFC Yum! Center on Thursday, starting at 7:00PM ET.

Based on updated simulation results, Dimers' new women's basketball model predicts South Carolina as the most likely winner of the South Carolina vs. Louisville game.

This article offers a closer look at Thursday's matchup, including best bets and picks.

South Carolina vs. Louisville prediction: Who will win?

Using innovative machine learning and statistical analysis, we have simulated the result of Thursday's women's basketball matchup between South Carolina and Louisville 10,000 times as part of our women's college basketball predictions coverage.

Our famous predictive model gives South Carolina a 94% chance of beating Louisville.

According to our model, the 139.5-point over/under has a 54% chance of staying under.

South Carolina vs. Louisville odds

We have researched the best women's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

South Carolina vs. Louisville picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: