South Carolina vs. LSU prediction: LSU favored to win in college football Week 7, 2025

LSU and South Carolina will clash in Week 7 college football action at Tiger Stadium on Saturday, commencing at 7:45PM ET.

Based on the latest simulations, Dimers' proven college football model predicts the LSU as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive South Carolina vs. LSU predictions page.

South Carolina vs. LSU prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the result of South Carolina vs. LSU 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives LSU a 71% chance of defeating South Carolina. Our predicted final score has LSU winning 27-19.

According to our model, South Carolina (+8.5) has a 52% chance of covering the spread, while the over/under total of 44.5 points has a 55% chance of staying under.

South Carolina vs. LSU odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	South Carolina	LSU
Spread	+8.5 (-105)	-8.5 (-112)
Moneyline	+275	-325
Total	o44.5 (-108)	u44.5 (-110)

All odds are correct at the time of publication and are subject to change.

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South Carolina vs. LSU picks and best bets

Our model's strongest edge in today's South Carolina vs. LSU matchup is on the spread.

Our expert predictions, aligned with the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

South Carolina vs. LSU game-day updates and essential details

Saturday's college football game between LSU and South Carolina at Tiger Stadium is scheduled to begin at 7:45PM ET.

• Who: South Carolina vs. LSU
• Date: Saturday, October 11, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Tiger Stadium

Dimers' comprehensive preview of Saturday's South Carolina vs. LSU matchup includes our prediction, picks and the latest betting odds.

Before making any South Carolina vs. LSU picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict LSU, with a 71% win probability, will likely beat South Carolina on Saturday.

AI and automation have enhanced this article to quickly deliver accurate South Carolina vs. LSU insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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More on college football

Keep up with the latest college football betting news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the most up-to-date probabilities for the national title game and major conferences.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.