South Carolina vs. Ole Miss prediction: Why Mississippi is favored to win in college football Week 10, 2025

Mississippi will take on South Carolina in Week 10 college football action at Vaught-Hemingway Stadium on Saturday, beginning at 7:00PM ET.

Based on updated simulation results, Dimers' proven college football model predicts the Mississippi as the most likely winner of the South Carolina vs. Ole Miss game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

South Carolina vs. Ole Miss prediction: Who will win, cover the spread?

Using trusted machine learning and statistical analysis, we have simulated the outcome of South Carolina vs. Ole Miss 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Mississippi an 80% chance of defeating South Carolina. Our predicted final score has Mississippi winning 33-20.

According to our model, the bookmakers have got it right, and South Carolina and Mississippi each have a 50% chance of covering the spread, while the 55.5-point over/under has a 54% chance of going over.

South Carolina vs. Ole Miss odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	South Carolina	Ole Miss
Spread	+12.5 (-105)	-12.5 (-115)
Moneyline	+400	-475
Total	o55.5 (-110)	u55.5 (-110)

All odds are correct at the time of publication and are subject to change.

South Carolina vs. Ole Miss picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	South Carolina +12.5	-105
Moneyline	South Carolina	+400
Total	Over 55.5	-110

According to our college football best bets, the top play to make on this game is Over 55.5 total points.

South Carolina vs. Ole Miss game-day updates and essential details

Saturday's college football game between Ole Miss and South Carolina at Vaught-Hemingway Stadium is scheduled to start at 7:00PM ET.

• Who: South Carolina vs. Mississippi
• Date: Saturday, November 1, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Vaught-Hemingway Stadium

Sports betting deal available for NCAAF Saturday

To make the most of Saturday's big day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that grants you $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict Mississippi, with an 80% win probability, will likely beat South Carolina on Saturday.

AI and automation have enhanced this article to quickly deliver accurate South Carolina vs. Mississippi insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Keep up with the latest college football betting news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds provide the latest projections for the national title game and major conferences.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.