South Dakota State vs. South Dakota prediction: South Dakota State favored to win in college football Week 11, 2025

South Dakota will take on the favored South Dakota State in Week 11 college football action at The DakotaDome on Saturday, commencing at 4:00PM ET.

Based on updated simulations, Dimers' proven college football model predicts South Dakota State as the most likely winner of the South Dakota State vs. South Dakota game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

South Dakota State vs. South Dakota prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the result of South Dakota State vs. South Dakota 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives South Dakota State a 69% chance of defeating South Dakota. Our predicted final score has South Dakota State winning 26-19.

According to our model, South Dakota (+7) has a 51% chance of covering the spread, while the 46.5-point over/under has an equal 50-50 chance of hitting.

South Dakota State vs. South Dakota odds

We have sourced the best College Football odds in America for this game, which are listed here:

Bet Type	South Dakota State	South Dakota
Spread	-7 (-110)	+7 (-110)
Moneyline	-250	+235
Total	o46.5 (-110)	u46.5 (-110)

All odds are correct at the time of publication and are subject to change.

South Dakota State vs. South Dakota picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	South Dakota +7	-110
Moneyline	South Dakota	+235
Total	Under 46.5	-110

According to our college football best bets, the top play to make on this game is South Dakota to win.

South Dakota State vs. South Dakota game-day updates and essential details

Saturday's college football matchup between South Dakota and South Dakota State at The DakotaDome is scheduled to commence at 4:00PM ET.

• Who: South Dakota State vs. South Dakota
• Date: Saturday, November 8, 2025
• Time: 4:00PM ET/1:00PM PT
• Venue: The DakotaDome

Sports betting deal available for NCAAF Saturday

To make the most of Saturday's big day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that secures $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict South Dakota State, with a 69% win probability, will likely beat South Dakota on Saturday.

AI and automation have enhanced this article to quickly deliver accurate South Dakota State vs. South Dakota insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Stay up-to-date with the latest college football news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the most accurate predictions for the national title game and major conferences.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.