CFB- More Betting
South Dakota vs. Mercer prediction: Why Mercer is favored to win in college football Week 15, 2025
Get South Dakota vs Mercer predictions for college football Saturday.

Mercer and South Dakota will lock horns in Week 15 college football action at Five Star Stadium on Saturday, with kickoff at 12:00PM ET.
Based on updated simulation results, Dimers' advanced college football model predicts Mercer as the most likely winner of the South Dakota vs. Mercer game.
This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
South Dakota vs. Mercer prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the outcome of South Dakota vs. Mercer 10,000 times as part of our college football predictions coverage.
Our famous predictive model gives Mercer a 60% chance of beating South Dakota. Our predicted final score has Mercer winning 30-26.
According to our model, South Dakota (+6) has a 53% chance of covering the spread, while the 53.5-point over/under has a 52% chance of staying under.
South Dakota vs. Mercer odds
We have sourced the best college football odds in America for this game, which are listed here:
| Bet Type | South Dakota | Mercer |
|---|---|---|
| Spread | +6 (-110) | -6 (-110) |
| Moneyline | +180 | -200 |
| Total | o53.5 (-115) | u53.5 (-104) |
All odds are correct at the time of publication and are subject to change.
South Dakota vs. Mercer picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | South Dakota +6 | -110 |
| Moneyline | South Dakota | +180 |
| Total | Under 53.5 | -104 |
According to our best college football bets, the top play to make on this game is South Dakota to win.
South Dakota vs. Mercer game-day updates and essential details
Saturday's college football matchup between Mercer and South Dakota at Five Star Stadium is scheduled to begin at 12:00PM ET.
- Who: South Dakota vs. Mercer
- Date: Saturday, December 6, 2025
- Time: 12:00PM ET/9:00AM PT
- Venue: Five Star Stadium
Sports betting deals available for Missouri sports betting launch
To truly take advantage of the recent Missouri launch, check out details on the latest Bet365 bonus code "DIMERS" that scores you the best opening offer in the game. Don't miss out!
Conclusion
We predict Mercer, with a 60% win probability, will likely beat South Dakota on Saturday.
AI and automation have enhanced this article to quickly deliver accurate South Dakota vs. Mercer insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.
