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South Dakota vs. Mercer prediction: Why Mercer is favored to win in college football Week 15, 2025

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Written by Mac Douglass

Get South Dakota vs Mercer predictions for college football Saturday.

South Dakota-Mercer Predictions and Game Preview.
South Dakota vs. Mercer college football gameday prediction for Saturday, December 6, 2025.

Mercer and South Dakota will lock horns in Week 15 college football action at Five Star Stadium on Saturday, with kickoff at 12:00PM ET.

Based on updated simulation results, Dimers' advanced college football model predicts Mercer as the most likely winner of the South Dakota vs. Mercer game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

South Dakota vs. Mercer prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of South Dakota vs. Mercer 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Mercer a 60% chance of beating South Dakota. Our predicted final score has Mercer winning 30-26.

According to our model, South Dakota (+6) has a 53% chance of covering the spread, while the 53.5-point over/under has a 52% chance of staying under.

 

South Dakota vs. Mercer odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type South Dakota Mercer
Spread +6 (-110) -6 (-110)
Moneyline +180 -200
Total o53.5 (-115) u53.5 (-104)

All odds are correct at the time of publication and are subject to change.

South Dakota vs. Mercer picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread South Dakota +6 -110
Moneyline South Dakota +180
Total Under 53.5 -104

According to our best college football bets, the top play to make on this game is South Dakota to win.

 

South Dakota vs. Mercer game-day updates and essential details

Saturday's college football matchup between Mercer and South Dakota at Five Star Stadium is scheduled to begin at 12:00PM ET.

  • Who: South Dakota vs. Mercer
  • Date: Saturday, December 6, 2025
  • Time: 12:00PM ET/9:00AM PT
  • Venue: Five Star Stadium

 

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Conclusion

We predict Mercer, with a 60% win probability, will likely beat South Dakota on Saturday.

AI and automation have enhanced this article to quickly deliver accurate South Dakota vs. Mercer insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Mac Douglass
Senior Editor

Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.

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