USF vs. Memphis prediction: Why South Florida is favored to win in college football Week 9, 2025

Memphis and South Florida will lock horns in Week 9 college football action at Simmons Bank Liberty Stadium on Saturday, starting at 12:00PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts the South Florida as the most likely winner of the USF vs. Memphis game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

USF vs. Memphis prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of USF vs. Memphis 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives South Florida a 54% chance of defeating Memphis. Our predicted final score has South Florida winning 29-28.

According to our model, Memphis (+3.5) has a 58% chance of covering the spread, while the 58.5-point over/under has a 58% chance of going over.

USF vs. Memphis odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	USF	Memphis
Spread	-3.5 (-105)	+3.5 (-110)
Moneyline	-168	+145
Total	o58.5 (-112)	u58.5 (-105)

All odds are correct at the time of publication and are subject to change.

USF vs. Memphis picks and best bet

Our probabilities, matched with the listed odds, reveal the top betting picks to make on this game, detailed in Dimers' college football best bets, crafted from expert modeling and analysis:

Bet Type	Pick	Bet Now
Spread	Memphis +3.5	-110
Moneyline	Memphis	+145
Total	Over 58.5	-112

According to our best college football bets, the top play to make on this game is Memphis +3.5 at the spread.

USF vs. Memphis game-day updates and essential details

Saturday's college football action between Memphis and USF at Simmons Bank Liberty Stadium is scheduled to start at 12:00PM ET.

• Who: South Florida vs. Memphis
• Date: Saturday, October 25, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Simmons Bank Liberty Stadium

Sports betting deal available for NCAAF Saturday

To make the most of Saturday's big day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that secures $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict South Florida, with a 54% win probability, will likely beat Memphis on Saturday.

AI and automation have enhanced this article to quickly deliver accurate South Florida vs. Memphis insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Keep up with the latest college football betting news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the most accurate projections for the national title game and major conferences.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.