...
...
Read Article
Southern Miss vs. South Alabama prediction: South Alabama favored to win in college football Week 13, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Southern Miss vs South Alabama predictions for college football Saturday.
South Alabama and Southern Miss will meet in Week 13 college football action at Hancock Whitney Stadium on Saturday, commencing at 3:30PM ET.
Based on the latest simulations, Dimers' advanced college football model gives South Alabama a slight edge with a 54% win probability over Southern Miss.
This article offers a closer look at Saturday's Southern Miss vs. South Alabama matchup, including an expanded look at the predicted score, best bets and picks.
Southern Miss vs. South Alabama prediction: Who will win and cover?
Using powerful machine learning and statistical analysis, we have simulated the outcome of Southern Miss vs. South Alabama 10,000 times as part of our college football predictions coverage.
Our famous predictive model currently gives South Alabama a 54% chance of defeating Southern Miss. Our predicted final score has South Alabama winning 26-24.
According to our model, South Alabama (+2.5) has a 56% chance of covering the spread, while the 53.5-point over/under has a 53% chance of going over.
Southern Miss vs. South Alabama odds
We have sourced the best College Football odds in America for this game, which are listed here:
| Bet Type | Southern Miss | South Alabama |
|---|---|---|
| Spread | -2.5 (-110) | +2.5 (-110) |
| Moneyline | -118 | +110 |
| Total | o53.5 (-105) | u53.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Southern Miss vs. South Alabama picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | South Alabama +2.5 | -110 |
| Moneyline | South Alabama | +110 |
| Total | Over 53.5 | -105 |
According to our college football best bets, the top play to make on this game is South Alabama to win.
Southern Miss vs. South Alabama game-day updates and essential details
Saturday's college football action between South Alabama and Southern Miss at Hancock Whitney Stadium is scheduled to commence at 3:30PM ET.
- Who: Southern Miss vs. South Alabama
- Date: Saturday, November 22, 2025
- Time: 3:30PM ET/12:30PM PT
- Venue: Hancock Whitney Stadium
Sports betting deal available for Missouri sports fans
To make the most of the upcoming Missouri launch, check out details on the latest Bet365 bonus code "DIMERS" that grants you $365 in bonus bets from a $10 bet — win or lose. Don't miss out!
Conclusion
We predict South Alabama, with a 54% win probability, will likely beat Southern Miss on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Southern Miss vs. South Alabama insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.
Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
Advertiser disclosure