Syracuse vs. Southern Methodist prediction: Southern Methodist favored to win in college football Week 6, 2025

Southern Methodist will face Syracuse in Week 6 college football action at Gerald J. Ford Stadium on Saturday, starting at 3:30PM ET.

Based on the latest simulation results, Dimers' advanced college football model predicts the Southern Methodist as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Syracuse vs. Southern Methodist predictions page.

Syracuse vs. Southern Methodist prediction: Who will win, cover the spread?

Using innovative machine learning and statistical analysis, we have simulated the result of Syracuse vs. Southern Methodist 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Southern Methodist an 86% chance of beating Syracuse. Our predicted final score has Southern Methodist winning 36-19.

According to our model, Southern Methodist (-15.5) has a 54% chance of covering the spread, while the 57.5-point over/under has a 52% chance of going over.

Syracuse vs. Southern Methodist odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Syracuse	Southern Methodist
Spread	+15.5 (-115)	-15.5 (-115)
Moneyline	+590	-660
Total	o57.5 (-105)	u57.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Syracuse vs. Southern Methodist picks and best bets

Our model's strongest edge in today's Syracuse vs. Southern Methodist matchup is on the spread.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Syracuse vs. Southern Methodist game-day updates and essential details

Saturday's college football matchup between Southern Methodist and Syracuse at Gerald J. Ford Stadium is scheduled to start at 3:30PM ET.

• Who: Syracuse vs. Southern Methodist
• Date: Saturday, October 4, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Gerald J. Ford Stadium

Dimers' comprehensive preview of Saturday's Syracuse vs. Southern Methodist matchup includes our prediction, picks and the latest betting odds.

Before making any Syracuse vs. Southern Methodist picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Southern Methodist, with an 86% win probability, will likely beat Syracuse on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Syracuse vs. Southern Methodist insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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